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Frequently asked
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Expand the boxes below to learn about HYMPAVZI

What is HYMPAVZI?
HYMPAVZI is a prescription medicine used regularly to prevent or reduce the frequency of bleeding episodes in adults and children 6 years of age and older with hemophilia A with or without factor VIII inhibitors or hemophilia B with or without factor IX inhibitors.
How is HYMPAVZI different from other hemophilia treatment options?

HYMPAVZI is the first once-weekly, subcutaneous prophylactic treatment for adults and children 6+ with hemophilia A or B, with or without inhibitors that comes in a fixed-dose* prefilled pen.

*For children ages 6 to less than 12, the first dose (loading dose) is 150 mg on day 1, then a weekly (maintenance) dose of 75 mg as prescribed by your healthcare provider. For adults and adolescents 12+, the first dose (loading dose) is 300 mg on day 1, then a weekly (maintenance) dose of 150 mg as prescribed by your healthcare provider. If more than 1 injection is required to deliver a complete dose, administer each injection at a different site.1

Why HYMPAVZI?

Is HYMPAVZI an option for people who have hemophilia A or B with inhibitors?

HYMPAVZI is indicated for routine prophylaxis in adults and children 6 years and older with hemophilia A or B, with or without inhibitors. The BASIS study included 51 people ages 12 and older with hemophilia A or B with inhibitors, and the BASIS KIDS study included 34 children 6 to less than 12 years of age with hemophilia A or B with inhibitors. Talk to your healthcare provider to determine whether HYMPAVZI is an appropriate option based on your individual treatment needs.

See the BASIS study results

Is HYMPAVZI FDA approved for use in children with hemophilia?

HYMPAVZI is indicated for routine prophylaxis in adults and children 6 years and older with hemophilia A or B, with or without inhibitors, and has been studied in children 6 to <18 in the BASIS KIDS study. Talk to your healthcare provider about whether HYMPAVZI may be right for you or a child under your care.

See the BASIS KIDS study results

How often do I take HYMPAVZI?

You should use HYMPAVZI once a week, any time of day, on the same day each week.

Learn how to take HYMPAVZI

How often do I give a dose of HYMPAVZI?
Use HYMPAVZI once a week, as prescribed by your healthcare provider, any time of day, on the same day each week.
Is monitoring required on HYMPAVZI?
HYMPAVZI does not require any treatment-related lab monitoring. Talk to your healthcare provider about condition-related lab monitoring that may be necessary.
How do I use the HYMPAVZI pen?

Read the full Instructions for Use for detailed administration information or watch the Instructions for Use video to learn more about how to inject.

How to take HYMPAVZI

How do I store the HYMPAVZI pen?
The HYMPAVZI pen is stored in the refrigerator (36°F to 46°F) until expiration. It can also be removed from the refrigerator and stored at room temperature (up to 86°F) in the original carton for up to 1 week. Once reaching room temperature, HYMPAVZI must not be returned to refrigerated storage and should be used or discarded. Keep the HYMPAVZI pen out of direct sunlight. Do not freeze or shake.
How do I know which dose is right for me?

Your healthcare provider will tell you which dose to take (or give to a child under your care).

For adults and adolescents 12+:

  • Loading dose: 300 mg (two 150 mg injections)
  • Maintenance dose: one once-weekly 150 mg injection

For people weighing 50 kg (110 lb) or more, your healthcare provider may change the maintenance dose to 300 mg weekly if the 150 mg maintenance dose is not enough to prevent bleeding events.

Your healthcare provider will determine which HYMPAVZI dose is right for you.

How do I know which dose is right for a child?

HYMPAVZI is a fixed-dose, prefilled pen available in 2 doses. The child's healthcare provider will determine which HYMPAVZI dose is right for the child under your care:

For adolescents 12+:

  • Loading dose: 300 mg (two 150 mg injections)
  • Maintenance dose: one once-weekly 150 mg injection

For people weighing 50 kg (110 lb) or more, their healthcare provider may change the maintenance dose to 300 mg weekly if the 150 mg maintenance dose is not enough to prevent bleeding events.

For children 6 to less than 12:

  • Loading dose: 150 mg (one 150 mg injection or two 75 mg injections)
  • Maintenance dose: one once-weekly 75 mg injection

For people weighing 25 kg (55 lb) or more, their healthcare provider may change the maintenance dose to 150 mg weekly if the 75 mg maintenance dose is not enough to prevent bleeding events.

Does HYMPAVZI dosing change as your child grows?
As they grow, a child’s treatment plan may be reassessed. The healthcare provider will consider factors such as age, weight, and overall treatment needs when deciding whether a dosing change is appropriate, including a possible transition to a once-weekly 150 mg dose. Always consult the healthcare provider before making any changes.
What do I do if I missed my dose?

If you miss a maintenance dose of 75 mg of HYMPAVZI:

  • Give the dose as soon as possible before the next scheduled dose, and then continue with your usual 75 mg weekly dosing schedule. You may inject your next dose at your regularly scheduled time or continue dosing based on the new day you injected your missed dose. In case you are not sure when to inject HYMPAVZI, call your healthcare provider
  • If more than 13 days have passed since your last dose was given, you will need to restart with a loading dose. Call your healthcare provider right away for dosing instructions

If you miss a maintenance dose of 150 mg of HYMPAVZI:

  • Give the dose as soon as possible before the day of your next scheduled dose, and then continue with your usual weekly dosing schedule. You may inject your next dose at your regularly scheduled time or continue dosing based on the new day you injected your missed dose. In case you are not sure when to inject HYMPAVZI, call your healthcare provider
  • If more than 13 days have passed since your last dose was given, you will need to restart with a loading dose. Call your healthcare provider right away for dosing instructions

If you miss 1 or more maintenance doses of 300 mg of HYMPAVZI:

  • Give a dose as soon as possible, and then continue with your usual weekly dosing schedule. You may inject your next dose at your regularly scheduled time or continue dosing based on the new day you injected your missed dose

In case you are not sure when to inject HYMPAVZI, call your healthcare provider.

Am I protected between intervals of dosing with HYMPAVZI?
Effective levels of HYMPAVZI are sustained throughout its once-weekly dosing administration. It takes your body 7-11 days to eliminate 50% of HYMPAVZI. Approximately 1 month after the last dose, 90% of HYMPAVZI is expected to be eliminated from your body.
How can I make sure I'm staying on track with my hemophilia treatment?

To help you stay on top of your treatment with HYMPAVZI, you can:

  • Download the HemMobile® app
    • HemMobile® is designed to help hemophilia patients with dosing reminders, recording bleeds, and tracking activity
    • HemMobile® is free and available to download from the Apple App Store and Google Play
  • Ask your healthcare provider about receiving a starter kit, which includes an injection tracker and other helpful tools and information to help you get started on HYMPAVZI
  • Set a reminder on your phone calendar
  • Record where you inject to make sure you change your injection site after every injection
  • Take your injection on the same day each week. Pick a weekly activity, like doing laundry, and do it then

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What do I do in an emergency, or while having surgery or dental care?

Emergencies happen, but you can stay prepared. You may want to carry a medication card in your wallet and update your emergency information in your phone. If you are a caregiver, make sure the child under your care also carries their medication card with them, and if they have a phone, make sure they update emergency information on their phone.

If you or the child have a planned surgery, your healthcare provider may stop treatment with HYMPAVZI before your surgery. Talk to your healthcare provider about when to stop using HYMPAVZI and when to start it again if you have a planned surgery.

Should I use HYMPAVZI for breakthrough bleeds?

Do not use HYMPAVZI to treat breakthrough bleeding.

Your healthcare provider will provide information on the treatment of breakthrough bleeding during your treatment with HYMPAVZI.

Before you start using HYMPAVZI, it is very important to talk to your healthcare provider about using factor VIII and factor IX products or bypassing agents (products that help blood clot but work in a different way than HYMPAVZI).

Your healthcare provider may prescribe factor VIII, factor IX medicines, or bypassing agents to treat episodes of breakthrough bleeding during your treatment with HYMPAVZI. Carefully follow your healthcare provider’s instructions regarding when to use factor VIII or factor IX medicines and the prescribed dose during your treatment with HYMPAVZI. Do not use additional doses of HYMPAVZI to treat breakthrough bleeds.

What support and resources are available?

Your healthcare team is your primary source for guidance and can provide information based on your or the child’s individual needs.

A range of support and resources is available to help you navigate treatment, including educational materials, information about financial support, and community support. Additional support may also be available through Pfizer Hemophilia Connect.

Resources & support

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