Not actual size. HYMPAVZI is available in a single-dose 150 mg prefilled pen and a single-dose 75 mg prefilled pen. The 150 mg pen is shown here.
Prefilled pen, minimal prep
How to take HYMPAVZI
Not an actual patient. Self-injection is for patients 12+ only.
HYMPAVZI is intended for use under the guidance of a healthcare provider. After proper training in subcutaneous injection technique, you may self-inject. If you are a caregiver of a child aged 6 to less than 12, you can administer HYMPAVZI after injection training.
Once-weekly dosing, designed to fit your schedule
After your first dose of 300 mg (2 subcutaneous injections) you only need to inject HYMPAVZI once a week. In the following weeks, you can take your dose the same day each week at any time of day. Each prefilled pen has a fixed dose of 150 mg. If more than 1 injection is required to deliver a complete dose, administer each injection at a different injection site.
For people weighing 50 kg or more, their healthcare provider may change the maintenance dose to 300 mg weekly if the 150 mg maintenance dose is not enough to prevent bleeding events.
After the first dose of 150 mg (either 1 or 2 subcutaneous injections), HYMPAVZI only needs to be injected once a week. In the following weeks, give the dose on the same day each week at any time of day. Each prefilled pen has a fixed dose of 75 mg. If more than one injection is required to deliver a complete dose, administer each injection at a different site.
For children ages 6 to less than 12 weighing 25 kg or more, their healthcare provider may change the maintenance dose to 150 mg weekly if the 75 mg maintenance dose is not enough to prevent bleeding events. Dose escalation should be discussed with the healthcare provider.
Watch the video to see how to inject HYMPAVZI step by step
HYMPAVZI is intended for use under the guidance of a healthcare provider. After proper training in subcutaneous injection technique, if you are 12 years of age you may self-inject, or a caregiver may administer HYMPAVZI.
Watch the video to see how to inject HYMPAVZI step by step
HYMPAVZI is intended for use under the guidance of a healthcare provider. After proper training in subcutaneous injection technique, if you are 12 years of age you may self-inject, or a caregiver may administer HYMPAVZI.
Overview of how to take HYMPAVZI
- Check the expiration date (EXP) printed on the pen label. Do not use if the expiration date has passed
- Look carefully at the medicine through the window. Do not use the pen if the medicine is cloudy, dark yellow, or contains flakes or particles
- Check the pen for any visible damage, such as cracks or leaks
- Wash and dry your hands
Injecting HYMPAVZI
Pick
- Next, pick and clean an injection site with soap and water or an alcohol swab and allow site to air dry
- After proper instruction, a caregiver may administer HYMPAVZI, if a healthcare provider determines it is appropriate. Thanks to its design and autoinjector delivery, you can inject HYMPAVZI into the thigh or abdomen.* As a caregiver, HYMPAVZI may also be injected into the buttocks by you or a healthcare provider only. HYMPAVZI should not be injected into a vein
- Change the injection site each time you inject HYMPAVZI. You may use the same body area, but be sure to choose a different injection site in that area
Twist
- Twist off the cap and place it in an FDA-cleared sharps container
- Handle the pen with care and avoid pressing your hand over the needle guard
Push
- Push straight down until you hear the first click
- This tells you that the injection has started
- Keep pushing the pen down firmly
Count
- After the second click, count slowly to 5
- If injecting someone under your care, keep the pen on their skin until the yellow marker completely fills the window. This means they received a full dose
- Press lightly on the injection site for a few seconds with a clean cotton ball or gauze pad if you see a drop of blood
- Dispose of the pen in an FDA-cleared sharps container
This HYMPAVZI Prefilled Syringe is for use in children 6 to less than 12 years of age and should be given by an adult caregiver only. Your child’s healthcare provider should show a caregiver how to prepare and inject HYMPAVZI before they use it for the first time. Do not inject anyone until you have been shown how to inject HYMPAVZI.
What to do if…
If you miss a maintenance dose of 150 mg of HYMPAVZI:
- Give the dose as soon as possible before the next scheduled dose, and then continue with your usual 150 mg weekly dosing schedule. You may inject your next dose at your regularly scheduled time or continue dosing based on the new day you injected your missed dose
- If more than 13 days have passed since the last dose was given, call the healthcare provider for the child in your care right away for dosing instructions
If you miss a maintenance dose of 75 mg of HYMPAVZI:
- Give the dose as soon as possible before the next scheduled dose, then continue with the usual 75 mg weekly dosing schedule. You may inject the next dose at the regularly scheduled time or continue dosing based on the day you injected the missed dose
- If more than 13 days have passed since the last dose was given, call the healthcare provider for you or the child in your care right away for dosing instructions
If you miss a maintenance dose of 300 mg of HYMPAVZI:
- Give a dose as soon as possible, and then continue with your 300 mg weekly dosing schedule. You may inject your next dose at your regularly scheduled time or continue dosing based on the new day you injected your missed dose
In case you are not sure when to inject HYMPAVZI, call your healthcare provider.
Do not use HYMPAVZI to treat breakthrough bleeding
- Your healthcare provider will provide information on the treatment of breakthrough bleeding during treatment with HYMPAVZI
- Before you start using HYMPAVZI, it is very important to talk to your or the child's healthcare provider about using factor VIII and factor IX products (products that help blood clot but work in a different way than HYMPAVZI). You may need to use factor VIII or factor IX medicines to treat episodes of breakthrough bleeding during treatment with HYMPAVZI
Emergencies happen, but you can stay prepared. You may want to carry a medication card in your wallet and update your emergency information in your phone. You may want to make sure the child also carries their medication card with them, and if they have a phone, make sure they update emergency information on their phone.
If there is a surgery or dental work planned, talk with your doctor to find out what to do before and after. Your healthcare provider may stop treatment with HYMPAVZI before a surgery.