Meet real patients

Video Transcript

00:00

Peter

My name is Peter. I'm 63. I have hemophilia A, severe, and was diagnosed at the age of two.

00:09

Peter

It was pretty rough back at that point because there was no real treatment at all except for whole blood. So, we would drive almost 2 hours to Hamilton, for treatment.

00:20

Peter

And then, I believe, when I was about ten, we finally were able to take the product home with us. When you're doing a factor replacement, you need alcohol wipes, a tourniquet, the whole procedure. You have to mix the product together, as opposed to opening the pen. Nothing to mix. You take it out of the fridge, and it’s done for you.

00:43

Peter

The discussions with my doctor about the products were very to the point. They said that there was a trial, if I'd be interested in it. Fewer injections and it didn't involve intravenous, so that obviously, caught my attention quickly.

1:01

Peter

I've been on it for at least a year and it’s very straightforward, and doesn’t consume much of my time.

1:10

Peter

I think the once-a-week dosing is definitely better for me. I chose Sunday nights. I’m sitting on the couch maybe watching the TV or, or some football or something, and it's so much easier for me just to do it at that point.

1:28

Peter

We do like to go away quite often and again it was always packing up a special amount of the product that I would take with me. How much do I have to bring with me?

1:41

Peter

Going away to Europe, three weeks, three pens. It was nice not being tied down with all the other product. The innovations mean I can concentrate on the things that are important to me.

1:56

Peter

What I enjoy about golf is being able to do it physically and just the freedom of clearing your head from other obstacles, and I think that's why everybody does play the game.

2:13

Peter

Everything I've gone through, I think meeting my wife and being with her is the silver lining in my life.

2:21

Peter

She began quilting probably ten years ago and then I would help her cut the fabric; we would work together like that.

2:34

Peter

I know that some people in studies had injection site reactions, headache, and itching, and that thromboembolic events are possible.

2:44

Peter

If somebody is considering HYMPAVZI, definitely talk to your doctor or to your hemophilia clinic. I'm certainly glad that I did.

2:52

Peter

Living with hemophilia I've had some rough patches. I've had some really incredible patches too. I managed to survive and thrive. Not just to exist, but to live, travel, see the world, have a partner.

3:17

Joanna

Is it nice?

3:18

Peter

Beautiful. Turned out very nice.

3:21

Joanna

Yeah, it's a beautiful color combination, right?

3:24

Peter

Ask your doctor about HYMPAVZI, and whether it would be right for you.

3:29

Voiceover

What is HYMPAVZI?

HYMPAVZI is a prescription medicine used to prevent or reduce the frequency of bleeding episodes in adults and children 12 years of age and older with hemophilia A without factor VIII inhibitors or hemophilia B without factor IX inhibitors.

It is not known if HYMPAVZI is safe and effective in children younger than 12 years old.

IMPORTANT SAFETY INFORMATION

Important: Before you start using HYMPAVZI, it is very important to talk to your healthcare provider about using factor VIII and factor IX products (products that help blood clot but work in a different way than HYMPAVZI). You may need to use factor VIII or factor IX medicines to treat episodes of breakthrough bleeding during treatment with HYMPAVZI. Carefully follow your healthcare provider’s instructions regarding when to use factor VIII or factor IX medicines and the prescribed dose during your treatment with HYMPAVZI.

Before using HYMPAVZI, tell your healthcare provider about all of your medical conditions, including if you:

• have a planned surgery. Your healthcare provider may stop treatment with HYMPAVZI before your surgery. Talk to your healthcare provider about when to stop using HYMPAVZI and when to start it again if you have a planned surgery.
• have a severe short-term (acute) illness such as an infection or injury.
• are pregnant or plan to become pregnant. HYMPAVZI may harm your unborn baby.

Females who are able to become pregnant:

• Your healthcare provider will do a pregnancy test before you start your treatment with HYMPAVZI.
• You should use effective birth control (contraception) during treatment with HYMPAVZI and for at least 2 months after the last dose of HYMPAVZI.
• Tell your healthcare provider right away if you become pregnant or think that you may be pregnant during treatment with HYMPAVZI.
• are breastfeeding or plan to breastfeed. It is not known if HYMPAVZI passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of HYMPAVZI? HYMPAVZI may cause serious side effects, including:

• blood clots (thromboembolic events). HYMPAVZI may increase the risk for your blood to clot. Blood clots may form in blood vessels in your arm, leg, lung, or head and can be life-threatening. Get medical help right away if you develop any of these signs or symptoms of blood clots: swelling or pain in arms or legs, redness or discoloration in your arms or legs, shortness of breath, pain in chest or upper back, fast heart rate, cough up blood, feel faint, headache, numbness in your face, eye pain or swelling, trouble seeing
• allergic reactions. Allergic reactions, including rash and itching have happened in people treated with HYMPAVZI. Stop using HYMPAVZI and get medical help right away if you develop any of the following symptoms of a severe allergic reaction: swelling of your face, lips, mouth, or tongue, trouble breathing, wheezing, dizziness or fainting, fast heartbeat or pounding in your chest, sweating

The most common side effects of HYMPAVZI are injection site reactions, headache, and itching.

These are not all the possible side effects of HYMPAVZI. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

6:43

Peter

Check out HYMPAVZI.com to learn more.

Video Transcript

00:00

Robert

Hi, my name's Robert, I'm 45 years old, and I was diagnosed with hemophilia A right at birth.

00:07

Robert

Living with hemophilia has got its challenges and hurdles to overcome, but I wasn't going to let that stop me from living a full life.

00:16

Robert

My son Reagan and I like to get in the car, go on our little road trips and find the best burger in town. And it’s something that we do, almost on a weekly basis. Talking about life and different things that come up. It's just our time to sort of bond, you know?

00:32

Robert

My childhood was very active. Played a lot of sports. Was very adventurous. Just kind of seeing what's out there and exploring.

00:38

Robert

Definitely, in the earlier years, there was restrictions on activities and things that I could do. You know, you got looked at a little bit differently. And that was, that was tough.

00:50

Robert

From a very young age, it was long hospital visits, hours in the waiting room. The next sort of evolution was, learning to self infuse, taking factor VIII. It was a big time commitment involved with the, uh, infusion process, multiple steps to go through, time to mix.

1:10

Robert

I think some of those experiences drove me towards martial arts and wanting to push those boundaries.

1:16

Robert

It was almost sort of like, you know, you tell me I can't do something. All right, well, I'm going to show you that I can.

1:22

Robert

I was always asking to be kept up with the latest developments and technologies, uh, in hemophilia care. After having a conversation with my physician, there were other drugs available, but they were not the right ones for me.

1:37

Robert

My physician made me aware of HYMPAVZI, so I said, well, put me at the front of the list [chuckles]. I'll do it.

1:47

Robert

I started HYMPAVZI in 2022 and I haven't looked back. I just give myself one injection with the pen, and that's it for the week. It comes prefilled and there's no mixing, no measuring. I don't even have to find a vein.

2:01

Robert

I decided to continue past the trial with HYMPAVZI, basically because the process is straightforward, it doesn't seem to be a bother.

2:10

Robert

I'm a huge fan of motorcycles, and motorcycle racing's always on Sunday. So, I thought, you know what? Sunday is the one day of the week… it's almost like ritual. Just wake up, administer it and then off with the day.

2:23

Robert

Hitting the open road. There's such a sense of freedom. No restrictions. Just driving around, listening to music. I think I've shared a lot of that with my son.

2:33

Robert

Reagan's very musically inclined. He's learning to do that, like, heavy metal screamer voice. [roars] I can't do it, but…

2:45

Robert

While I did not experience side effects, I know that some people in the studies had injection site reactions, headache, and itching, and that thromboembolic events are possible.

2:56

Waitress

Alright. I have the burgers there for you.

2:59

Robert and Reagan

Thank you. Thank you.

2:59

Waitress

You’re welcome. Enjoy!

3:01

Robert

Long trip. Well worth it.

3:03

Reagan

Cheers.

3:04

Robert

Cheers.

3:06

Robert

For anyone that's thinking of HYMPAVZI, I would encourage that conversation with your physician. It's been such a positive experience for myself.

3:17

The subcutaneous injections have been a welcome change to my treatment routine.

3:22

Robert

All right, bud.

3:23

Reagan

Cheers.

3:28

Robert

That’s real good!

3:29

Robert

Talk to your doctor about HYMPAVZI and whether it might be right for you.

3:36

Voiceover

What is HYMPAVZI?

HYMPAVZI is a prescription medicine used to prevent or reduce the frequency of bleeding episodes in adults and children 12 years of age and older with hemophilia A without factor VIII inhibitors or hemophilia B without factor IX inhibitors.

It is not known if HYMPAVZI is safe and effective in children younger than 12 years old.

IMPORTANT SAFETY INFORMATION

Important: Before you start using HYMPAVZI, it is very important to talk to your healthcare provider about using factor VIII and factor IX products (products that help blood clot but work in a different way than HYMPAVZI). You may need to use factor VIII or factor IX medicines to treat episodes of breakthrough bleeding during treatment with HYMPAVZI. Carefully follow your healthcare provider’s instructions regarding when to use factor VIII or factor IX medicines and the prescribed dose during your treatment with HYMPAVZI.

Before using HYMPAVZI, tell your healthcare provider about all of your medical conditions, including if you:

• have a planned surgery. Your healthcare provider may stop treatment with HYMPAVZI before your surgery. Talk to your healthcare provider about when to stop using HYMPAVZI and when to start it again if you have a planned surgery.
• have a severe short-term (acute) illness such as an infection or injury.
• are pregnant or plan to become pregnant. HYMPAVZI may harm your unborn baby.

Females who are able to become pregnant:

• Your healthcare provider will do a pregnancy test before you start your treatment with HYMPAVZI.
• You should use effective birth control (contraception) during treatment with HYMPAVZI and for at least 2 months after the last dose of HYMPAVZI.
• Tell your healthcare provider right away if you become pregnant or think that you may be pregnant during treatment with HYMPAVZI.

• are breastfeeding or plan to breastfeed. It is not known if HYMPAVZI passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of HYMPAVZI?

HYMPAVZI may cause serious side effects, including:

• blood clots (thromboembolic events). HYMPAVZI may increase the risk for your blood to clot. Blood clots may form in blood vessels in your arm, leg, lung, or head and can be life-threatening. Get medical help right away if you develop any of these signs or symptoms of blood clots: swelling or pain in arms or legs, redness or discoloration in your arms or legs, shortness of breath, pain in chest or upper back, fast heart rate, cough up blood, feel faint, headache, numbness in your face, eye pain or swelling, trouble seeing
• allergic reactions. Allergic reactions, including rash and itching have happened in people treated with HYMPAVZI. Stop using HYMPAVZI and get medical help right away if you develop any of the following symptoms of a severe allergic reaction: swelling of your face, lips, mouth, or tongue, trouble breathing, wheezing, dizziness or fainting, fast heartbeat or pounding in your chest, sweating

The most common side effects of HYMPAVZI are injection site reactions, headache, and itching.

These are not all the possible side effects of HYMPAVZI. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

6:47

Robert

Using HYMPAVZI has been worth it for me.